Sulforaphane and it's effects on cancer

 Sulforaphane is found in Brocholi

Sulforaphane is found in Brocholi

Isothiocyanates are some of the most important plant compounds you can get in your diet. In this video I make the most comprehensive case for them that has ever been made. Short attention span? Skip to your favorite topic by clicking one of the time points below. Full timeline below the fold...

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Key sections:
00:01:14 - Cancer and mortality
00:19:04 - Aging
00:26:30 - Brain and behavior
00:38:06 - Final recap
00:40:27 - Dose

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Full timeline:
00:00:34 - Introduction of sulforaphane, a major focus of the video.
00:01:14 - Cruciferous vegetable consumption and reductions in all-cause mortality.
00:02:12 - Prostate cancer risk.
00:02:23 - Bladder cancer risk.
00:02:34 - Lung cancer in smokers risk.
00:02:48 - Breast cancer risk.
00:03:13 - Hypothetical: what if you already have cancer? (interventional)
00:03:35 - Plausible mechanism driving the cancer and mortality associative data.
00:04:38 - Sulforaphane and cancer.
00:05:32 - Animal evidence showing strong effect of broccoli sprout extract on bladder tumor development in rats.
00:06:06 - Effect of direct supplementation of sulforaphane in prostate cancer patients.
00:07:09 - Bioaccumulation of isothiocyanate metabolites in actual breast tissue.
00:08:32 - Inhibition of breast cancer stem cells.
00:08:53 - History lesson: brassicas were established as having health properties even in ancient Rome.
00:09:16 - Sulforaphane's ability to enhance carcinogen excretion (benzene, acrolein).
00:09:51 - NRF2 as a genetic switch via antioxidant response elements.
00:10:10 - How NRF2 activation enhances carcinogen excretion via glutathione-S-conjugates.
00:10:34 - Brussels sprouts increase glutathione-S-transferase and reduce DNA damage.
00:11:20 - Broccoli sprout drink increases benzene excretion by 61%.
00:13:31 - Broccoli sprout homogenate increases antioxidant enzymes in the upper airway.
00:15:45 - Cruciferous vegetable consumption and heart disease mortality.
00:16:55 - Broccoli sprout powder improves blood lipids and overall heart disease risk in type 2 diabetics.
00:19:04 - Beginning of aging section.
00:19:21 - Sulforaphane-enriched diet enhances lifespan of beetles from 15 to 30% (in certain conditions).
00:20:34 - Importance of low inflammation for longevity.
00:22:05 - Cruciferous vegetables and broccoli sprout powder seem to reduce a wide variety of inflammatory markers in humans.
00:23:40 - Mid-video recap: cancer, aging sections
00:24:14 - Mouse studies suggest sulforaphane might improve adaptive immune function in old age.
00:25:18 - Sulforaphane improved hair growth in a mouse model of balding. Picture at 00:26:10.
00:26:30 - Beginning of brain and behavior section.
00:27:18 - Effect of broccoli sprout extract on autism.
00:27:48 - Effect of glucoraphanin on schizophrenia.
00:28:17 - Start of depression discussion (plausible mechanism and studies).
00:31:21 - Mouse study using 10 different models of stress-induced depression show sulforaphane similarly effective as fluoxetine (prozac).
00:32:00 - Study shows direct ingestion of glucoraphanin in mice is similarly effective at preventing depression from social defeat stress model.
00:33:01 - Beginning of neurodegeneration section.
00:33:30 - Sulforaphane and Alzheimer's disease.
00:33:44 - Sulforaphane and Parkinson's disease.
00:33:51 - Sulforaphane and Hungtington's disease.
00:34:13 - Sulforaphane increases heat shock proteins.
00:34:43 - Beginning of traumatic brain injury section.
00:35:01 - Sulforaphane injected immediately after TBI improves memory (mouse study).
00:35:55 - Sulforaphane and neuronal plasticity.
00:36:32 - Sulforaphane improves learning in model of type II diabetes in mice.
00:37:19 - Sulforaphane and duchenne muscular dystrophy.
00:37:44 - Myostatin inhibition in muscle satellite cells (in vitro).
00:38:06 - Late-video recap: mortality and cancer, DNA damage, oxidative stress and inflammation, benzene excretion, cardiovascular disease, type II diabetes, effects on the brain (depression, autism, schizophrenia, neurodegeneration), NRF2 pathway.
00:40:27 - Thoughts on figuring out a dose of broccoli sprouts or sulforaphane.
00:41:01 - Anecdotes on sprouting at home.
00:43:14 - On cooking temperatures and sulforaphane activity.
00:43:45 - Gut bacteria conversion of sulforaphane from glucoraphanin.
00:44:24 - Supplements work better when combined with active myrosinase from vegetables.
00:44:56 - Cooking techniques and cruciferous vegetables.
00:46:06 - Isothiocyanates as goitrogens.

Vitamin D

How important is Vitamin D? Very important if you want to live longer and be healthier. We have all heard this before, but why and how does it help us? Get those telomeres protected and stop them from prematurely shortening and speeding up the aging process. Check out this short video from one of my favorite doctors, as Dr. Patrick explains how important the sun is for us in the right dose.

Check out the Video

Ketosis Expert Dr. Dominic D'Agostino

Check out the latest episode by Dr. Rhonda Patrick on Ketosis, a slow/low carb eating plan which uses good fats as an energy source as opposed to carbs/sugar. I have been following this diet since my cancer diagnosis with the hypothesis that if the cancer has no fuel (SUGAR) it will struggle to grow/replicate and I could essentially "starve" it out. Not only do I feel amazing, have great energy and mentally sharp as a tac, I am the leanest I have been ever with great muscle mass. Take a listen to her interview with Dr. Dominic D'Agostino who is an expert on the subject it will be well worth your time. There is a ton of info here folks so sit back and dig in, enjoy.

CLICK HERE TO LISTEN

 

Energize Your Body by Energizing Your Cells - The Budwig Mixture

In this video I explain how to make the Budwig Mixture which is one of the protocols I use daily. I am currently fighting Melanoma skin cancer and this is my go to protocol and pretty much the holy grail in my opinion. You do not have to be sick or in a state of dis-ease to use this though. Anyone can incorporate this protocol to help strengthen their body as a preventative measure. 

HERE IS THE VIDEO LINK - ENERGIZE BODY BY ENERGIZING YOUR CELLS - THE BUDWIG MIXTURE

The Budwig Diet, meaning the Budwig Protocol is not actually not a “diet,” but rather a specific mixture is necessary for many alternative treatments; from type 2 diabetes to cancer to heart disease to auto-immune diseases, etc.

Its purpose is to energize the cells by restoring the natural electrical balance in the cell. Many human diseases are caused by “sick cells” which have lost their normal electrical balance; generally via a lower ATP energy in the cell’s mitochondria.

One thing to understand, and this is critical, is that the WHOLE purpose of the Budwig 'Diet' is to convert oil-soluble omega-3 fatty acids into water-soluble omega-3 fatty acids.

This is why it is so important to add things to the mixture in the right order. If you mix them in the wrong order you may lose a lot of the opportunity to convert the oil-soluble omega-3s into water soluble-omega-3s.

Here is the Video Link - Energize Body by Energizing Your Cells - The Budwig Mixture

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It's PODCAST #8 on her feed.

In this episode Rhonda talks about how heat stress from using the sauna makes the body more resilient to the stresses of aging, possible reasons why one study associated sauna use with up to a 40% lower all-cause mortality as well as a 50% lower cardiovascular disease related mortality, how it enhances athletic endurance, staves off muscle atrophy, improves regrowth of muscle after disuse, and some of the profound effects on the brain, including the growth of new brain cells, improvement in focus, learning, and memory, and even potentially ameliorating depression and anxiety. She also talks about how BPA, PCBs, phthalates, and other metals are excreted through sweat. In addition, she addresses some practical applications like temperature and duration in the sauna, the difference between a dry, wet and infrared sauna, sauna timing, as well as other forms of heat stress such as steam showers, hot baths, and hot yoga.

PODCAST LINK

https://itunes.apple.com/…/podc…/foundmyfitness/id818198322…

Sauna I purchased on AMAZON to start my journey

http://www.amazon.com/gp/product/B00MX19M9E/ref=as_li_tl…">Radiant Saunas BSA6310